Humans have been displaced at the top of the food chain, and now understand – to their outright horror – what it is to be not the consumer, but the consumed.

Ephraim Goodweather, director of the New York office of the Centers for Disease control, is one of the few humans who understands what is really happening. Vampires have arrived in New York City, and their condition is contagious. If they cannot be contained, the entire world is at risk of infection.

As Eph becomes consumed with the battle against the total corruption of humanity, his ex-wife, Kelly, now a vampire herself, is ever-more determined to claim their son, Zack.

As the Biblical origins of the Ancient ones are gradually revealed, Eph learns that there is a greater, more terrible plan in store for the human race – worse even than annihilation…